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You are here:Home » Antibodies » Abs to Synaptophysin » Anti -Synaptophysin (SYP, SYPH, SypI, Major Synaptic Vesicle Protein P38, Syn p38) (BIotin)

Anti -Synaptophysin (SYP, SYPH, SypI, Major Synaptic Vesicle Protein P38, Syn p38)
(BIotin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH FC
This antiobody labels normal neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, gastrointestinal mucosa, Paneth’s cells in the gastrointestinal tract and of gastric parietal cells. Neurons in the brain, spinal cord, and retina are also labeled. Anti-synaptophysin reacts with neuroendocrine neoplasms of neural as well as epithelial types e.g. neuroblastomas, ganglioneuroblastomas. ganglioneuromas, pheo-chromocytomas, chromaffin, and non-chromaffin paragangliomas. Epithelial types include pituitary adenomas, islet cell neoplasms, medullathyroid carcinomas, parathyroid adenomas, carcinoids of the bronchopulmonary and gastro-intestinal tracts and neuroendocrine carcinomas of the skin. In combination with anti-chromogranin A and anti-NSE, anti-synaptophysin is very useful in the identification of normal neuroendocrine cells and neuroendocrine neoplasms.
Catalog #S9108-09D
ApplicationsSuitable for use in Flow Cytometry and Immunohistochemistry (frozen and paraffin embedded tissue and cytological material). Other applications not tested.
Recommended DilutionImmunohistochemistry: 1:10 with PBS, pH 7.4; Incubation Time 1hr at RT. Do NOT use protease pre-treatment.
Optimal dilution to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5F304
HostMouse
SourceBovine
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.4.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynaptophysin from presynaptic vesicles, prepared from bovine brain.
SpecificityExcellent marker for several neuroendocrine tumors of epithelial origin (pancreatic islet cell carcinoma, bronchial and gastrointestinal carcinoids, medullary carcinoma of thyroid) for neuronal and adrenal tumors (pheochromocytomas, paragangliomas, neuroblastomas, ganglioneuroblastomas). Reacts with transmembrane glycoprotein (Mr 38kD) in synaptic vesicles. Species reactivity: human, bovine, rat and mouse. Also reacts with rat PC-12 cell line.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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