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You are here:Home » Antibodies » Abs to Synaptophysin » Anti -Synaptophysin (SYP, SYPH, SypI, Major Synaptic Vesicle Protein P38, Syn p38) (BIotin)

Anti -Synaptophysin (SYP, SYPH, SypI, Major Synaptic Vesicle Protein P38, Syn p38)
(BIotin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH FC
Synaptophysin labels normal neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, gastrointestinal mucosa, Paneth’s cells in the gastrointestinal tract and of gastric parietal cells. Neurons in the brain, spinal cord, and retina are also labeled. Anti-synaptophysin reacts with neuroendocrine neoplasms of neural as well as epithelial types e.g. neuroblastomas, ganglioneuroblastomas. ganglioneuromas, pheo-chromocytomas, chromaffin, and non-chromaffin paragangliomas. Of the epithelial types include pituitary adenomas, islet cell neoplasms, medullathyroid carcinomas, parathyroid adenomas, carcinoids of the bronchopulmonary and gastro-intestinal tracts and neuroendocrine carcinomas of the skin. In combination with anti-chromogranin A and anti-NSE, anti-synaptophysin is very useful in the identification of normal neuroendocrine cells and neuroendocrine neoplasms.
Catalog #S9108-09D
ApplicationsSuitable for use in FACS and Immunohistochemistry (frozen and paraffin embedded tissue and cytological material, Pretreatment: In no case protease pretreatment).
Recommended DilutionImmunohistochemistry: 1:10 with PBS, pH 7.4; Incubation Time 1 hr at RT.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5F304
HostMouse
SourceBovine
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.4.
PurityPurified IgG
ImmunogenSynaptophysin from presynaptic vesicles, prepared from bovine brain.
SpecificityRepresents an excellent marker for several neuroendocrine, neuronal and adrenal tumors. Neuronal and adrenal tumors such as pheochromocytomas, paragangliomas, neuroblastomas, ganglioneuroblastomas. Neuroendocrine tumors of epithelial origin
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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