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Anti -Synaptophysin, NT (Major Synaptic Vesicle Protein p38, SYP)
Anti -Synaptophysin, NT (Major Synaptic Vesicle Protein p38, SYP)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IH |
|
| Synaptophysin is a transmembrane glycoprotein present in neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body. This protein consists of four transmembrane domains, with its amino- and carboxyl-terminus facing the cytoplasm. Coltage-dependent channel activity is seen when synaptophysin hexamers are reconstituted into lipid membranes, reminiscent of gap-junction proteins. Synaptophysin appears to be a significant cholesterol-binding protein in brain synaptic vesicles. A regioselective downregulation of synaptophysin is found in patients with Alzheimer.s disease and schizophrenia. | | | Catalog # | S9108-15A | | Applications | Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | ELISA: 1:1,000 | | Western Blot: 1:50-1:100 | | Immunohistochemistry: 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide selected from the N-terminal region of human Synaptophysin (KLH). | | Specificity | Recognizes human Synaptophysin. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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