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You are here:Home » Antibodies » Abs to Syntaxin, Synaptotagmin, Synaptophysin » Anti -Synaptotagmin (SYT, DKFZp781D2042, P65, SVP65, Synaptotagmin I, SYT1, SYT-1, SytI, SYT2, SYT3)

Anti -Synaptotagmin (SYT, DKFZp781D2042, P65, SVP65, Synaptotagmin I, SYT1, SYT-1, SytI,
SYT2, SYT3)

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Affinity Purified IH IC
Synaptotagmins are integral membrane proteins of synaptic vesicles that are thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Catalog #S9108-98A
ApplicationsSuitable for use in Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostChicken
SourceMouse
Concentration~0.4mg/ml
FormPBS [pH7.2] containing 0.02% sodium azide
PurityPurified by immunoaffinity chromatography.
ImmunogenFour different affinity-purified anti-peptide antibodies were combined to make this product from human (NP_005630, NCBI) and mouse (NP_033332, NCBI) peptide shared sequences. The concentrations of each of the four antibodies was 100 ug/ml (based on Bradford assay readings using bovine serum albumin as a standard), making the total antibody concentration 400 ug/ml.
SpecificitySpecies Crossreactivity: Reacts with mouse Synaptotagmin. Other species have not been tested. Homology with human is 100% for the immunizing peptides.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesP65, SVP 65, SVP65, Synaptotagmin I, SYT 1, SYT, SYT1, SYTI


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