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You are here:Home » Antibodies » Abs to Syntaxin, Synaptotagmin, Synaptophysin » Anti -Synaptotagmin, phosphorylated (Ser309) (SYT, Synaptotagmin-1, SYT1, Synaptotagmin I, SytI, p65, SVP65)

Anti -Synaptotagmin, phosphorylated (Ser309) (SYT, Synaptotagmin-1, SYT1, Synaptotagmin I,
SytI, p65, SVP65)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the presynaptic active zone of nerve terminals (1). Synaptic vesicles undergo a trafficking cycle to support rapid and repeated cycles of neurotransmitter release. Calcium-triggered exocytosis is the focal point of the vesicle cycle, which is followed by different routes of endocytosis and recycling. Recycling then leads to the docking and priming of the vesicles for another round of exocytocis and endocytosis. The synaptotagmins are integral membrane proteins of synaptic vesicles. Synaptotagmins may serve as the calcium sensors that trigger neuortransmitter release (2,3). More than 13 synaptotagmins have been described, and synaptotagmin I is among the best characterized isoforms. Synaptotagmin I is an abundant constituent of synaptic vesicles that binds calcium ions through two C2 domains. It is thought that synaptotagmin I triggers exocytosis in a calcium dependent manner, and may also play a key role in endocytosis following membrane fusion. Synaptotagmin is phosphorylated by multiple protein kinases, and these phosphorylation events may play a regulatatory role in both exocytotic and endocytotic events.
Catalog #S9108-99P
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlRat brain
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM HEPES (pH 7.5), 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to amino acids residues surrounding phosphorylated (Ser309) of synaptotagmin.
SpecificityRecognizes human Synaptotagmin, phosphorylated at (Ser309). Species crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesDKFZp781D2042


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