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You are here:Home » Antibodies » Abs to Syntaxin, Synaptotagmin, Synaptophysin » Anti -Synaptotagmin 1 (Synaptotagmin-1, SYT1, Synaptotagmin I, SytI, P65)

Anti -Synaptotagmin 1 (Synaptotagmin-1, SYT1, Synaptotagmin I, SytI, P65)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Synaptotagmin 1 is a 60kD member of the synaptotagmin family, expressed in membranes of synaptic vesicles in rostral, phylogenetically younger brain regions and in some endocrine tissues. Ca2+ is bound by synaptogamin whose C2 domains then bind phospholipids, trafficking vesicles to the synaptic membrane and exocytosis. This results in fast synchronous neurotransmitter release. Synaptotagmin also binds neurexins, syntaxin and AP2 independently of Ca2+ binding.
Catalog #S9109-19B
Phosphorylation of synaptotagmin by protein kinases is thought to modulate its activity.
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as a liquid in 10mM Hepes, pH 7.5, 0.09% sodium azide, 0.01% BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa sequence within synaptotagmin 1.
SpecificityRecognizes rat synaptotagmin 1. Species sequence homology: Mouse, Primate, Bovine, Chicken, Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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