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You are here:Home » Antibodies » Abs to Membrane Proteins » Anti -Syndecan 2

Anti -Syndecan 2

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified E IH
Syndecans are cell surface heparan sulfate proteoglycans that act as co-receptors for growth factor binding, cell-matrix interactions, and cell-cell interactions to regulate cell adhesion, proliferation, and differentiation. Syndecan-2 interacts with matrix proteins such as laminin and fibronectin, and its cytoplasmic V region controls matrix assembly at the cell surface. Syndecan-2 is essential for angiogenic sprouting during embryogenesis and controls the growth of normal human osteoblastic cells. Syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.
Catalog #S9111-40B1
ApplicationsSuitable for use in Direct ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA (Direct): 0.5-1ug/ml. Detection limit for rhSyndecan-2 is ~10ng/well.
Immunohistochemistry: 25ug/ml Detects Syndecan-2 in paraffin-embedded normal human skin tissue sections.
Optimal dilutions to be determined by the researcher.
HybridomaNSO myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypeMonoclonal
IsotypeIgG2a
Clone No7H78
HostRat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenNS0-derived recombinant human Syndecan-2 (aa 19-144; Accession # P34741)
SpecificityRecognizes human Syndecan-2. In direct ELISAs, does not crossreact with recombinant mouse Syndecan-1, recombinant human Syndecan-3 or recombinant human Syndecan-4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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