STX6 (Syntaxin 6) is a 30-35kD member of the syntaxin family of proteins. It is widely expressed, embedded in trans-Golgi and endosomal membranes, and is associated with a variety of SNARE proteins. STX6 is involved in the regulation of caveolae-dependent endocytosis, and is crucial for membrane remodeling. Human STX6 is a type IV single-pass transmembrane protein (very long cytoplasmic N-terminus) that is 255 amino acids (aa) in length. It contains a coiled-coil region (aa 41-74), a t-SNARE domain (aa 163-225) that is likely involved in protein-protein interactions, and a C-terminal transmembrane sequence. There are two splice variants that are also 255 aa in length, but show variation over aa 69-73. Over aa 69-217, human STX6 shares 93% aa identity with mouse STX6.