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You are here:Home » Antibodies » Abs to Syntaxin, Synaptotagmin, Synaptophysin » Anti -STXBP1 (Syntaxin-binding Protein 1, N-Sec1, Protein unc-18 Homolog 1, Unc18-1, Protein unc-18 Homolog A, Unc-18A, p67, UNC18A)

Anti -STXBP1 (Syntaxin-binding Protein 1, N-Sec1, Protein unc-18 Homolog 1, Unc18-1,
Protein unc-18 Homolog A, Unc-18A, p67, UNC18A)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
STXBP1 (Syntaxin-binding protein 1; also p67, Munc18-1, N-Sec1 and Unc18A) is a 67kD member of the SNARE-interacting Sec1/Unc18/STXBP family of proteins. It is expressed in a variety of cells, presumably in those that exhibit granule exocytosis, and likely participates in (synaptic) granule release. Ligands for STXBP1 include STX1A, 2 and 3, and it is possible that STXBP1 both suppresses STX activity, and serves as an anchor for STX-mediated vesicle fusion. Human STXBP1 is 594aa in length. It contains one SEC1 domain (aa41-575). Phosphorylation at Ser313 may stimulate granule release. There is one splice variant that shows a 28aa substitution for aa576-594. This is restricted to neural tissue. Over aa80-226, human and
mouse STXBP1 are absolutely identical in amino acid sequence.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Catalog #S9205-80
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified.
ImmunogenSTXBP1 (NP_003156.1, 1-603aa) full-length human protein.
SpecificityRecognizes human STXBP1. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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