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Abs to Syntaxin, Synaptotagmin, Synaptophysin
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Anti -STXBP1 (Syntaxin-binding Protein 1, N-Sec1, Protein unc-18 Homolog 1, Unc18-1, Protein unc-18 Homolog A, Unc-18A, p67, UNC18A)
Anti -STXBP1 (Syntaxin-binding Protein 1, N-Sec1, Protein unc-18 Homolog 1, Unc18-1,
Protein unc-18 Homolog A, Unc-18A, p67, UNC18A)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
B |
|
| STXBP1 (Syntaxin-binding protein 1; also p67, Munc18-1, N-Sec1 and Unc18A) is a 67kD member of the SNARE-interacting Sec1/Unc18/STXBP family of proteins. It is expressed in a variety of cells, presumably in those that exhibit granule exocytosis, and likely participates in (synaptic) granule release. Ligands for STXBP1 include STX1A, 2 and 3, and it is possible that STXBP1 both suppresses STX activity, and serves as an anchor for STX-mediated vesicle fusion. Human STXBP1 is 594aa in length. It contains one SEC1 domain (aa41-575). Phosphorylation at Ser313 may stimulate granule release. There is one splice variant that shows a 28aa substitution for aa576-594. This is restricted to neural tissue. Over aa80-226, human and | | | mouse STXBP1 are absolutely identical in amino acid sequence. | | | | | | Applications: | | | Suitable for use in Western Blot. Other applications not tested. | | | Catalog # | S9205-80 | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap. | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.2. | | Purity | Purified. | | Immunogen | STXBP1 (NP_003156.1, 1-603aa) full-length human protein. | | Specificity | Recognizes human STXBP1. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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