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You are here:Home » Antibodies » Abs to Syntaxin, Synaptotagmin, Synaptophysin » Anti -Syntaxin-binding Protein 1 (STXBP1, FLJ37475, MUNC18-1, NSEC1, N-Sec1, Protein unc-18 Homolog 1, Unc18-1, Protein unc-18 Homolog A, Unc-18A, p67, RBSEC1, UNC18, UNC18A)

Anti -Syntaxin-binding Protein 1 (STXBP1, FLJ37475, MUNC18-1, NSEC1, N-Sec1, Protein
unc-18 Homolog 1, Unc18-1, Protein unc-18 Homolog A, Unc-18A, p67, RBSEC1, UNC18, UNC18A)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Munc-18, otherwise known as STXBP1, is a syntaxin-binding, pre-synaptic protein and member of the STXBP/UNC-18/SEC1 family, expressed in the brain and spinal cord, and at significantly high levels in neuronal axons. Munc-18 is a vital component of the synaptic vesicle fusion protein complex, playing a critical role in calcium-dependent neurotransmitter release, and in the regulation of the exocytosis of neurons and neuroendocrine cells. Studies have shown that isoform a of Munc-18 (Munc 18-1/Munc18a), acts as a regulator of insulin secretion from pancreatic beta cells.
Catalog #S9205-80B
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-0.3ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman Brain lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to CSRVSFEDQAPTME, from the C-terminus of the protein sequence according to NP_003156.1.
SpecificityRecognizes human STXBP1. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesHunc18, RP11-56D16.3


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