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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, alpha (SNCA, 127750, P37840, MGC110988, NACP, PARK1, PARK4, non-A beta Component of AD Amyloid, NACP, Parkinson Disease Familial 1, PD1)

Anti -Synuclein, alpha (SNCA, 127750, P37840, MGC110988, NACP, PARK1, PARK4, non-A beta
Component of AD Amyloid, NACP, Parkinson Disease Familial 1, PD1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH
alpha-Synuclein is a small (140 amino acid) cytoplasmic protein of unclear function that is enriched in presynaptic terminals and is the precursor protein of a nonamyloid beta component of senile plaques in Alzeheimer's Disease (AD). Alpha-Synuclein is located predominantly in the presynaptic nerve terminals in the brain but is also found in low concentrations in all tissues except liver. Recent studies have shown that abnormal aggregation and accumulation of synaptic proteins, including alpha-Synuclein might be associated with plaque formation in AD and seems to be a major component of Lewy bodies in dementia with Lewy bodies (DLB). It has also been identified in the Glial Cytoplasmic Inclusions (GCIs) found in Multiple System Atrophy (MSA).
Catalog #S9500-04
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000 shows a band at 14-19kD
Immunohistochemistry (frozen or paraffin sections):
Frozen sections: 1:4000-1:12,000
Paraffin sections: 1:1000-1:2000
Optimal dilutions to be determined by the researcher.
Positive ControlHuman brain sections
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile 40-50% glycerol, ddh2O. Aliquot and store at -20°C. Reconstituted product is stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a lyophilized powder. No preservative added. Reconstitute with 50ul sterile 40-50% glycerol, ddH2O.
PuritySerum
ImmunogenHuman alpha-synuclein aa111-131 (KLH coupled).
SpecificityRecognizes human synuclein, alpha. Immunohistochemistry and
Western Blot analysis of human brain indicates a high level of
specificity. Crossreactivity with beta-synuclein is minimal.
Species CrossreactivityRat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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