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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, alpha

Anti -Synuclein, alpha

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
This antibody recognizes a-synuclein, which belongs to a family of small cytoplasmic proteins expressed predominantly in neurons. The epitope maps to amino acid residues 121-125 of human a-synuclein. a-synuclein may be involved in neuronal plasticity and could act as a molecular chaperone that mediates the transformation of soluble AB into insoluble amyloid. The protein is a major component of Lewy bodies, the pathological hallmark of Parkinsonís disease, and is also observed in senile plaques of Alzheimerís disease patients. Human a-synuclein appears to be phosphorylated at two major sites, serine 129 and serine 87, and phosphorylation may play a role in the functional regulation of the protein.
Catalog #S9500-08
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1.0ug/ml
Immunohistochemistry: formalin-fixed paraffin sections
Optimal dilutions to be determined by the researcher.
Recommended Positive Control Human SHSY-5Y cells.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2B2.99
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.1% sodium azide.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant human a-synuclein.
SpecificityRecognizes alpha-synuclein (19kD). Species Crossreactivity: Human. Does not crossreact with mouse or rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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