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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E B IH

This antibody recognizes a-synuclein, which belongs to a family of small cytoplasmic proteins expressed predominantly in neurons. The epitope maps to amino acid residues 121-125 of human a-synuclein. a-synuclein may be involved in neuronal plasticity and could act as a molecular chaperone that mediates the transformation of soluble AB into insoluble amyloid. The protein is a major component of Lewy bodies, the pathological hallmark of Parkinson’s disease, and is also observed in senile plaques of Alzheimer’s disease patients. Human a-synuclein appears to be phosphorylated at two major sites, serine 129 and serine 87, and phosphorylation may play a role in the functional regulation of the protein.
Catalog #	S9500-08
Applications	Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution	Western Blot: 0.5-1.0ug/ml
	Immunohistochemistry: formalin-fixed paraffin sections
	Optimal dilutions to be determined by the researcher.
Recommended Positive Control	Human SHSY-5Y cells.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	2B2.99
Host	Mouse
Source	Human
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.1% sodium azide.
Purity	Purified by Protein A/G affinity chromatography.
Immunogen	Recombinant human a-synuclein.
Specificity	Recognizes alpha-synuclein (19kD). Species Crossreactivity: Human. Does not crossreact with mouse or rat.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.