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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, alpha

Anti -Synuclein, alpha

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH
Synnuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimerís (AD), Parkinsonís (PD) and breast cancer. In AD, a peptide derived from alpha-synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha-synuclein accumulates in Lewy bodies. An allele of alpha-synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
Catalog #S9500-11
ApplicationsSuitable for use in Western Blot, Immnoprecipitation and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionImmunohistochemistry (formalin/paraffin): 1:200 for 30 min at RT
Note: Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Optimal dilutions to be determined by the researcher.
Positive ControlBrain
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No3F344
HostMouse
SourceHuman
Concentration0.1mg/ml
FormSupplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide before the addition of glycerol to 40%. Also available without BSA and azide. See S9500-11X
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman recombinant alpha-synuclein.
Cellular LocalizationNeuronal cytosol and presynaptic terminals
MW of Antigen~14kD
SpecificityRecognizes Human recombinant alpha-synuclein.
Species CrossreactivityHighly specific for alpha-synuclein and does not react with other synuclein subtypes. Does not react with mouse or rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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