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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, alpha (SNCA, 127750, P37840, MGC110988, NACP, PARK1, PARK4, non-A beta Component of AD Amyloid, NACP, Parkinson Disease Familial 1, PD1)

Anti -Synuclein, alpha (SNCA, 127750, P37840, MGC110988, NACP, PARK1, PARK4, non-A beta
Component of AD Amyloid, NACP, Parkinson Disease Familial 1, PD1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B IP
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. An early step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43aa peptides (beta amyloid1-40, 1-42, and 1-43). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Ab deposits have also been found to contain 2 additional proteins termed a-synuclein and b-synuclein. The 140aa a-synuclein is identical with non-Ab component (NACP) of AD. The 134aa b-synuclein is homologous to 14kD bovine phosphoneuroprotein 14. Mutations in a-synuclein gene causing a replacement of alanine with a threonine has the potential to cause the protein to misfold.
Catalog #S9500-20A
ApplicationsSuitable for use in Western Blot, ELISA, and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:1,000-1:5,000
ELISA: 1:10,000-1:100,000; 50-100ng of control peptide/well
Immunoprecipitation: 5-10ul
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to 15aa located near the C-terminus of human synuclein-alpha (KLH).
SpecificityRecognizes human synuclein-alpha.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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