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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, alpha, CT (SNCA, 127750, P37840, MGC110988, NACP, PARK1, PARK4, non-A beta Component of AD Amyloid, NACP, Parkinson Disease Familial 1, PD1)

Anti -Synuclein, alpha, CT (SNCA, 127750, P37840, MGC110988, NACP, PARK1, PARK4, non-A
beta Component of AD Amyloid, NACP, Parkinson Disease Familial 1, PD1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. An early step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43aa peptides (beta amyloid1-40, 1-42, and 1-43). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Ab deposits have also been found to contain 2 additional proteins termed a-synuclein and b-synuclein. The 140aa a-synuclein is identical with non-Ab component (NACP) of AD. The 134aa b-synuclein is homologous to 14kD bovine phosphoneuroprotein 14. Mutations in a-synuclein gene causing a replacement of alanine with a threonine has the potential to cause the protein to misfold.
Catalog #S9500-21A
ApplicationsSuitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended DilutionELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well
Western Blot: 1-10ug/ml.
Optimal dilutions to be determined by the researcher.
Control Peptide S9500-21P
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% BSA, 40% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 15aa located near the C-terminus of human synuclein-alpha.
SpecificityRecognizes human a-Synuclein CT. No significant homology is seen with beta-synuclein or with other known proteins. Species sequence homology
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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