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Anti -Synuclein, alpha (Non-A beta Component Of AD Amyloid, Non-A4 Component Of Amyloid Precursor, NACP, SNCA, PARK1)
Anti -Synuclein, alpha (Non-A beta Component Of AD Amyloid, Non-A4 Component Of Amyloid
Precursor, NACP, SNCA, PARK1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IF |
|
| Alpha-synuclein (aa1-140), an acidic neuronal protein of 140aa, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-A beta component of amyloid plaques (NAC, aa61-95) is a highly amyloidogenic peptide consisting of 35aa which was first identified associated with senile plaques in the Alzheimer's disease brain. | | | Catalog # | S9500-22A | | Applications | Suitable for use in Immunofluorescence. Other applications not tested. | | Recommended Dilution | Immunofluorescence: 1:100-1:200 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic phosphopeptide corresponding to human a-Synuclein around the phosphorylation site of tyrosine 133 (E-G-YP-Q-D). | | Specificity | Recognizes human a-Synuclein only when phosphorylated at tyrosine 133. Species Crossreactivity: Mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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