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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, alpha (Non-A beta Component Of AD Amyloid, Non-A4 Component Of Amyloid Precursor, NACP, SNCA, PARK1)

Anti -Synuclein, alpha (Non-A beta Component Of AD Amyloid, Non-A4 Component Of Amyloid
Precursor, NACP, SNCA, PARK1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Alpha-synuclein (aa1-140), an acidic neuronal protein of 140aa, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-A beta component of amyloid plaques (NAC, aa61-95) is a highly amyloidogenic peptide consisting of 35aa which was first identified associated with senile plaques in the Alzheimer's disease brain.
Catalog #S9500-22D
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human a-Synuclein around the phosphorylation site of tyrosine 136 (Q-D-YP-E-P).
SpecificityRecognizes human a-Synuclein. Species Crossreactivity: Rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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