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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, alpha

Anti -Synuclein, alpha

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP IH
Human a-Synuclein is predominantly a presynaptic neuronal protein that has been localized in close proximity to synaptic vesicles. Studies have revealed that this protein is mostly cytosolic, although a fraction may be associated with vesicular membranes. In addition, a-synuclein binds to small synthetic unilamellar vesicles and rat brain vesicles, suggesting that a-synuclein may play a role in neurotransmission or in the organization and regulation of synaptic vesicles. a-Synuclein has been reported to be a major component of Lewy bodies in Parkinsonís disease, as well as dementia and Alzheimerís disease. In recent studies, antibodies to b- and g-synuclein have been used to investigate the biological functions of a-synuclein as well as its role in neurodegenerative disorders.
Catalog #S9500-26
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and ELISA. Other applications not tested.
Recommended DilutionsWestern Blot: 1-3ug/ml
Immunohistochemistry: Paraffin sections
Immunoprecipitation: Native
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No3G281
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide
PurityPurified by Protein A affinity chromatography
ImmunogenRecombinant protein corresponding to human alpha-synuclein.
SpecificityRecognizes human alpha-synuclein protein. Does not crossreact with beta or gamma synuclein or synoretin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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