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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, alpha, beta

Anti -Synuclein, alpha, beta

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP IH IF
Human a-Synuclein is predominantly a presynaptic neuronal protein that has been localized in close proximity to synaptic vesicles. Studies have revealed that this protein is mostly cytosolic, although a fraction may be associated with vesicular membranes. In addition, a-synuclein binds to small synthetic unilamellar vesicles and rat brain vesicles, suggesting that a-synuclein may play a role in neurotransmission or in the organization and regulation of synaptic vesicles. a-Synuclein has been reported to be a major component of Lewy bodies in Parkinsonís disesease, as well as dementia and Alzheimerís disease. In recent studies, antibodies to b- and g-synuclein have been used to investigate the biological functions of a-synuclein as well as its role in neurodegenerative disorders.
Catalog #S9500-28
ApplicationsSuitable for use in Western Blot, ELISA, Immunoprecipitation, Immunohistochemistry and Immunofluorescence. Other applications not tested.
Recommended DilutionWestern Blot: 1-3ug/ml
Immunohistochemistry: Paraffin sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No3G283
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant human alpha and beta synuclein
SpecificityRecognizes the human alpha and beta synuclein proteins. Does not crossreact with gamma synuclein or synoretin.
Species CrossreactivityMouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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