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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, beta (Phosphoneuroprotein 14, PNP14, SYN)

Anti -Synuclein, beta (Phosphoneuroprotein 14, PNP14, SYN)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant E B IH
The synucleins are a family of soluble presynaptic proteins that are abundant in neurons and include a- synuclein (alphaS) (aka the nonamyloid component of plaques precursor protein or NACP), _- synuclein (betaS) (aka phosphoneuroprotein 14 or PNP14) and _-synuclein (gammaS) (also known as breast cancer-speci c gene 1 or BCSG1 and persyn). Although they are homologous, each synuclein is encoded by a different gene on chromosomes 4q21.3-q22 (alphaS), 5q35 (betaS), and 10q23 (gammaS). A critical balance among products of the synuclein gene is important to maintain normal brain function and that alterations in this balance might be associated with neurodegenerative disorders. _-synuclein, the non-amyloidogenic homolog of a-synuclein, has been characterized as an inhibitor of the aggregation of a-synuclein, a molecule implicated in Parkinsonís disease. _-synuclein may be a natural negative regulator of a-synuclein aggregation and that a similar class of endogenous factors may regulate the aggregation state of other molecules involved in neurodegeneration. Human a-Synuclein is predominantly a presynaptic neuronal protein that has been localized in close proximity to synaptic vesicles. Although the functions of a-, _-, and _-synuclein are unknown, these synaptic proteins are implicated in the pathogenesis of Parkinsonís disease (PD) and related disorders. a-, _-, and _-synuclein may play a functional role in the development and maturation of substantia nigra (SN) neurons but it remains to be determined how sequestration of _-synuclein as Lewy Bodies in Parkinson Disease contributes to the degeneration of SN neurons.
Catalog #S9500-29
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 0.1Ė1.0ug/ml
Western Blot: 1:50-1:200
Immunohistochemistry(paraffin) : 1:10-1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgM
Clone No3G284
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PuritySupernatant
ImmunogenRecombinant human beta synuclein.
SpecificityRecognizes human beta-synuclein protein at ~17kD. Does not crossreact with alpha and gamma synuclein or synoretin. Species Crossreactivity: mouse and rat in Western Blot. Speci city was con rmed with recombinant alpha-synuclein and beta-synuclein in a Western Blot assay.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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