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Abs to Synuclein
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Anti -Synuclein, beta (Phosphoneuroprotein 14, PNP14, SYN)
Anti -Synuclein, beta (Phosphoneuroprotein 14, PNP14, SYN)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
E B IH |
|
| The synucleins are a family of soluble presynaptic proteins that are abundant in neurons and include a- synuclein (alphaS) (aka the nonamyloid component of plaques precursor protein or NACP), _- synuclein (betaS) (aka phosphoneuroprotein 14 or PNP14) and _-synuclein (gammaS) (also known as breast cancer-speci c gene 1 or BCSG1 and persyn). Although they are homologous, each synuclein is encoded by a different gene on chromosomes 4q21.3-q22 (alphaS), 5q35 (betaS), and 10q23 (gammaS). A critical balance among products of the synuclein gene is important to maintain normal brain function and that alterations in this balance might be associated with neurodegenerative disorders. _-synuclein, the non-amyloidogenic homolog of a-synuclein, has been characterized as an inhibitor of the aggregation of a-synuclein, a molecule implicated in Parkinson’s disease. _-synuclein may be a natural negative regulator of a-synuclein aggregation and that a similar class of endogenous factors may regulate the aggregation state of other molecules involved in neurodegeneration. Human a-Synuclein is predominantly a presynaptic neuronal protein that has been localized in close proximity to synaptic vesicles. Although the functions of a-, _-, and _-synuclein are unknown, these synaptic proteins are implicated in the pathogenesis of Parkinson’s disease (PD) and related disorders. a-, _-, and _-synuclein may play a functional role in the development and maturation of substantia nigra (SN) neurons but it remains to be determined how sequestration of _-synuclein as Lewy Bodies in Parkinson Disease contributes to the degeneration of SN neurons. | | | Catalog # | S9500-29 | | Applications | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | ELISA: 0.1–1.0ug/ml | | Western Blot: 1:50-1:200 | | Immunohistochemistry(paraffin) : 1:10-1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgM | | Clone No | 3G284 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide. | | Purity | Supernatant | | Immunogen | Recombinant human beta synuclein. | | Specificity | Recognizes human beta-synuclein protein at ~17kD. Does not crossreact with alpha and gamma synuclein or synoretin. Species Crossreactivity: mouse and rat in Western Blot. Speci city was con rmed with recombinant alpha-synuclein and beta-synuclein in a Western Blot assay. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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