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Anti -Synuclein-beta (Phosphoneuroprotein 14, PNP14, SYN)
Anti -Synuclein-beta (Phosphoneuroprotein 14, PNP14, SYN)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH |
|
| Synuclein-beta is a 19kD, 134aa cytoplasmic phosphoprotein that is a member of a family of small, highly conserved proteins, including synucleins alpha, beta, and gamma (synoretin), localized predominantly in presynaptic nerve terminals in the brain. Synuclein-beta associates with Synuclein-alpha, preventing it from aggregating. Abnormal Synuclein-alpha aggregates form filamentous inclusions (Lewy bodies) in neurodegenerative diseases including Parkinson's disease. Within the region used as an immunogen, human SNCB shares 99% aa identity with mouse and rat Synuclein-beta. | | | Catalog # | S9500-29A | | Applications | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | ELISA: 0.5-1.0ug/ml | | Western Blot: 2ug/ml | | Immunohistochemistry: 25ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | 9H182 | | Host | Mouse | | Source | Human | | Concentration | ~500ug/ml | | Form | Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant human Synuclein-beta aa47-120; Q16143 (E. coli). | | Specificity | Recognizes human Synuclein-beta. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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