Synuclein-beta is a 19kD, 134aa cytoplasmic phosphoprotein that is a member of a family of small, highly conserved proteins, including synucleins alpha, beta, and gamma (synoretin), localized predominantly in presynaptic nerve terminals in the brain. Synuclein-beta associates with Synuclein-alpha, preventing it from aggregating. Abnormal Synuclein-alpha aggregates form filamentous inclusions (Lewy bodies) in neurodegenerative diseases including Parkinson's disease. Within the region used as an immunogen, human SNCB shares 99% aa identity with mouse and rat Synuclein-beta.
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