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Specifications

Clone Host Grade Applications Monoclonal Mouse Highly Purified E B Gel

Synuclein-alpha is the major component of Lewy bodies and Lewy neuritis in sporadic PD. dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20kDa) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma-synuclein and synoretin. The expression is abundant in neurons and typically localized at presynaptic terminals.
Catalog #	S9500-30
Source	Tissue culture supernatant
Applications	Suitable for use in Western/Dot Blot, ELISA, Immunohistochemistry (Frozen and formalin-fixed paraffin-embedded tissues. No formic acid, enzyme or HIER required).
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	2B84
Host	Mouse
Source	Human
Concentration	As reported
Form	Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
Purity	Purified by ammonium sulfate precipitation.
Immunogen	Purified E. coli produced human alpha-synuclein
Specificity	Recognizes human alpha-synuclein.
Important Note	This product is intended for research use only, not for use in human, therapeutic or diagnostic applications.