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Anti -Synuclein, beta CT (Phosphoneuroprotein 14, PNP14)
Anti -Synuclein, beta CT (Phosphoneuroprotein 14, PNP14)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. One of the most important and initial step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43aa peptides (beta amyloid1–40, 1–42, and 1–43). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Ab deposits have also been found to contain 2 additional proteins termed a-synuclein and b-synuclein. The 140 aa a-synucleins is identical with non-Ab component (NACP) of AD. The 134aa b-synuclein is homologous to 14kD bovine phosphoneuroprotein 14. Mutations in a-synuclein gene causing a replacement of alanine with a threonine has the potential to cause the protein to misfold. Synucleins are primarily expressed in the brain. At least 3 forms, two large (140aa SYN-1 & 149 aa SYN-2) and a small form (SYN-3, 42 aa) are produced by alternative splicing. | | | Catalog # | S9501-05 | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well | | Western Blot: 1-10 ug/ml using Chemiluminescence technique | | Optimal dilutions to be determined by the researcher. | | Control Peptide | S9501-05P Synuclein, beta Human CT Control Peptide | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.1% BSA, 40% glycerol. | | Purity | Purified by antigen affinity chromatography. | | Immunogen | Sunthetic 15 aa peptide located near the C-terminus of human synuclein-beta (KLH). | | Specificity | Recognizes human Synuclein. The peptide sequence corresponding to human beta-synuclein (134 aa). Species sequence homology: rat beta-synuclein (137 aa) and bovine PNP14 (134 aa). It has no appreciable homology with synuclein-alpha or other proteins. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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