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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, beta CT (Phosphoneuroprotein 14, PNP14)

Anti -Synuclein, beta CT (Phosphoneuroprotein 14, PNP14)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. One of the most important and initial step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43aa peptides (beta amyloid1–40, 1–42, and 1–43). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Ab deposits have also been found to contain 2 additional proteins termed a-synuclein and b-synuclein. The 140 aa a-synucleins is identical with non-Ab component (NACP) of AD. The 134aa b-synuclein is homologous to 14kD bovine phosphoneuroprotein 14. Mutations in a-synuclein gene causing a replacement of alanine with a threonine has the potential to cause the protein to misfold. Synucleins are primarily expressed in the brain. At least 3 forms, two large (140aa SYN-1 & 149 aa SYN-2) and a small form (SYN-3, 42 aa) are produced by alternative splicing.
Catalog #S9501-05A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:10,000-1:100,000 using 50–100ng of control peptide/well
Western Blot: 1:1000-1:5000
Optimal dilutions to be determined by the researcher.
Control PeptideS9501-05P Synuclein, beta Human CT Control Peptide
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSerum
PuritySerum
Immunogen15 aa peptide located near the C-terminus of human synuclein-beta
SpecificityRecognizes human Synuclein. The peptide sequence corresponding to human beta-synuclein (134 aa). Species sequence homology: rat beta-synuclein (137 aa) and bovine PNP14 (134 aa). It has no appreciable homology with synuclein-alpha or other proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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