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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, beta (Phosphoneuroprotein 14, PNP14, SYN)

Anti -Synuclein, beta (Phosphoneuroprotein 14, PNP14, SYN)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: a-synuclein, b-Synuclein, and g-Synuclein. All Synucleins have in common a highly conserved a-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins. Although they are homologous, each Synuclein is encoded by a different gene on chromosomes 4q21.3-q22. b-Synuclein, also known as PNP 14, is expressed in the brain, specifically in synapses around neurons, but not in glial cells. The protein, which has also been designated as a phosphoneuroprotein, has been found to be phosphorylated in vitro and in vivo.
Catalog #S9501-07
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:2000-1:4000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.4, 0.02% Thimerosal.
PurityPurified from rabbit whole serum by Protein A affinity chromatography.
ImmunogenRecombinant human b-Synuclein purified from E. coli
SpecificitySpecific for human b-Synuclein. Does not crossreact with a- and g-Synuclein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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