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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E B IH

Synuclein, gamma is a 127aa protein (~14kD) which belongs to the synuclein family, which also includes alpha- and beta- synuclein. Three synucleins are located in the neuronal cytosol and enriched in presynaptic terminals, while SYN is also expressed in many other non-neuronal tissues. SYN is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer, but rarely expressed in tumor-matched nonneoplastic adjacent tissues. High levels of SYN have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SYN and breast tumor development.
Catalog #	S9502-04A
Applications	Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested.
Recommended Dilutions	Western Blot: 1:500-1:2000
	Immunohistochemistry (Paraffin, formalin): 1:500-1:2000
	ELISA: 1:10,000
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	8A254
Host	Mouse
Source	Human
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, pH 7.6, 0.02% sodium azide, 50% glycerol.
Purity	Purified by Protein A affinity chromatography.
Immunogen	Ni-NTA purified truncated recombinant Synuclein, gamma (SYN) expressed in E. coli strain BL21 (DE3).
Specificity	Recognizes human SYN recombinant protein, truncated SYN recombinant protein and human ovary and breast carcinoma.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.