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You are here:Home » Antibodies » Abs to Synuclein » Anti -Synuclein, gamma (BCSG1, SYN)

Anti -Synuclein, gamma (BCSG1, SYN)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Synuclein, gamma is a 127aa protein (~14kD) which belongs to the synuclein family, which also includes alpha- and beta- synuclein. Three synucleins are located in the neuronal cytosol and enriched in presynaptic terminals, while SYN is also expressed in many other non-neuronal tissues. SYN is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer, but rarely expressed in tumor-matched nonneoplastic adjacent tissues. High levels of SYN have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SYN and breast tumor development.
Catalog #S9502-04A
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested.
Recommended DilutionsWestern Blot: 1:500-1:2000
Immunohistochemistry (Paraffin, formalin): 1:500-1:2000
ELISA: 1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No8A254
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.6, 0.02% sodium azide, 50% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenNi-NTA purified truncated recombinant Synuclein, gamma (SYN) expressed in E. coli strain BL21 (DE3).
SpecificityRecognizes human SYN recombinant protein, truncated SYN recombinant protein and human ovary and breast carcinoma.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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