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You are here:Home » Antibodies » Antibodies-Carbohydrates, Glycoproteins » Anti -Tamm-Horsfall Glycoprotein (Uromucoid, THgp, Uromodulin, UMOD)

Anti -Tamm-Horsfall Glycoprotein (Uromucoid, THgp, Uromodulin, UMOD)


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Clone Host Grade Applications
Polyclonal Sheep Affinity Purified E B
Tamm-Horsfall glycoprotein (THP, Uromodulin) is a 105-120kD urinary glycoprotein. It is secreted by renal tubule epithelium, acts as a binding protein for IL-1, TNF-alpha and C1q, activates resting monocytes, and promotes neutrophil phagocytosis. Uromodulin forms high molecular weight oligomers that line the kidney tubules. Mouse Uromodulin is GPI-linked. Its proprecursor is 619aa in length. It contains three EGF-like domains (aa28-148), a ZP domain that mediates oligomerization (aa335-590), and a cleavable C-terminal propeptide (aa619- 642). There are multiple splice variants. One shows an alternate start site at Met343, and there are two substitutions, a 17aa substitution for aa601-642, and a 166aa substitution for aa441- 642. Over aa25-614, mouse Uromodulin shares 78% and 89%aa identical to human and rat Uromodulin, respectively.
Suitable for use in ELISA and Western Blot. Other applications not tested.
Catalog #T0850-02B
Recommended DilutionsDirect ELISA: 0.5-1.0ug/ml. The detection limit is ~0.3ng/well.
Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
PurityPurified by affinity chromatography. Endotoxin: <0.1 EU/ug (LAL)
ImmunogenNS0-derived, recombinant mouse Tamm-Horsfall Glycoprotein (aa24-618, Accession #Q91X17).
SpecificityRecognizes mouse Tamm-Horsfall Glycoprotein. Shows <5% crossreactivity with recombinant human Tamm-Horsfall Glycoprotein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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