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You are here:Home » Antibodies » Abs to Carbohydrates, Glycoproteins » Anti -Tamm-Horsfall Glycoprotein (Uromucoid, THgp, THP, Uromodulin, UMOD) (Biotin) (BSA, Azide & Glycerol free)

Anti -Tamm-Horsfall Glycoprotein (Uromucoid, THgp, THP, Uromodulin, UMOD) (Biotin) (BSA,
Azide & Glycerol free)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Purified IH
Tamm-Horsfall glycoprotein (Uromucoid, THgp, Uromodulin, UMOD), which is synthesized by renal tubular cells, is the most abundant protein in normal human urine. Although its physiological function remains unclear, it has been proposed that Uromucoid, THgp, Uromodulin, UMOD may act as a defence factor against urinary tract infections by inhibiting the binding of S- and P-fimbriated Escherichia coli to renal epithelial cells. Because Uromucoid, THgp, Uromodulin, UMOD-related proteins are also found in the superficial layers of the oral mucosa, Uromucoid, THgp, Uromodulin, UMOD may interfere with the cytoadherence of pathogenic bacteria that colonize mucosal surfaces other than those of the urogenital tract. It has been shown that Uromucoid, THgp, Uromodulin, UMOD binds to virulent Bordetella pertussis and reduces its adherence to both renal and pulmonary epithelial cells. This cytoadherence inhibitory effect was not observed with a B. pertussis mutant lacking the pertussis toxin (PTX) operon, and was dependent on the direct interaction of Uromucoid, THgp, Uromodulin, UMOD with the S2 subunit within the PTX B oligomer.
Catalog #T0850B1
ApplicationsSuitable for use in IEP, RID, Double Diffusion and Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in PBS, pH 7.2. No preservative added. No stabilizing proteins added. Glycerol free. Labeled with Biotin.
PurityPurified
ImmunogenHighly purified human Tamm-Horsfall glycoprotein (uromucoid) from urine. (SDS-PAGE > 95%).
SpecificityRecognizes Tamm-Horsfall Glycoprotein. One arc by 2D-IEP against Tamm-Horsfall glycoprotein (1mg/ml). No precipitin line by IEP against normal human plasma. Identity verified by double immunodiffusion.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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