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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau (Tau Protein, Microtubule-associated Protein, MAP)

Anti -Tau (Tau Protein, Microtubule-associated Protein, MAP)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Tau is a heterogeneous group of proteins that range in molecular weight from 50-67kD. They are instumental in the assembly of microtubules and have been associated with some disease states. In normal brain, tau is localized in the axons of the neurons but in some neuropathological lesions, it accumulates within the body of the neuron. Tau protein is a microtubule-associated protein predominantly localized to neuronal axons. Tau promotes tubulin polymerization and the stabilization of microtubules. In vivo this protein is enriched in the exonal compartment of neurons wherer it has a role in the rapid elongation of the axon. Hyperphosphorylated forms of Tau are the major components of paired helical filaments
(PHF) found in the neurofibrillary tangles which characterize Alzheimer’s disease. Alternate splicing of tau mRNA, glycosylation, and differential phosphorylation contribute to the heterogeneity of tau.
Catalog #T1030
ApplicationsSuitable for use in ELISA, Western Blot and Immunhistochemsitry. Other applications not tested.
Recommended DilutionsWestern Blot: 0.5-2ug/ml detected tau proteins (50-70kD) in rat brain preparations.
Immunohistochemistry: 20ug/ml detected tau proteins in rat brain sections.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No0.T.147
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman fetal heat-stable MAPS.
SpecificityRecognizes several bands of human Tau protein between 50kD and 70kD. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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