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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau (Microtubule-associated Protein tau, MAPT, DDPAC, FTDP-17, FLJ31424, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, Neurofibrillary Tangle Protein, Paired Helical Filament-tau, PHF-tau, PPND)

Anti -Tau (Microtubule-associated Protein tau, MAPT, DDPAC, FTDP-17, FLJ31424, MAPTL,
MGC138549, MSTD, MTBT1, MTBT2, Neurofibrillary Tangle Protein, Paired Helical
Filament-tau, PHF-tau, PPND)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH
Tau is the major microtubule-associated protein in neuronal axons that regulates microtubule stability, neurite outgrowth, and other microtubule -dependent functions. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Six tau isoforms are produced in adult Human brain by alternative mRNA splicing from a single gene. Inclusion of a 31 amino acid repeat encoded by exon 10 of the tau gene gives rise to the three isoforms with four microtubule-binding repeats each. The other three isoforms have three repeats each. Abundant neurofibrillary lesions made of the protein constitute a defining neuropathological characteristic of Alzheimer's disease. Filamentous tau protein deposits are also the defining characteristic of other neurodegenerative diseases, many of which are frontotemporal dementias or movement disorders, such as Pick's disease, progressive supranuclear palsy, and corticobasal degeneration.
Catalog #T1030-01R
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlAlzheimerís disease brain
Cellular Localization
Cytoplasmic
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 0.05% sodium azide.
PuritySerum
ImmunogenRecombinant protein encoding C-terminal part of human Tau.
SpecificityRecognizes human Tau.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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