You are here:Home
»
Antibodies
»
Abs to Microtubule-associated Proteins
»
Anti -Tau (Tau Protein, Microtubule Associated Protein tau, Microtubule-associated Protein tau, MAPT, MGC134287, Neurofibrillary Tangle Protein, Paired Helical Filament-tau, PHF-tau)
Anti -Tau (Tau Protein, Microtubule Associated Protein tau, Microtubule-associated Protein
tau, MAPT, MGC134287, Neurofibrillary Tangle Protein, Paired Helical Filament-tau,
PHF-tau)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
B IH |
|
| Tau is a low molecular weight component of cytoskeletal structures, normally functions as a microtubule associated protein, presumably by stabilizing the microtubules which serve as tracks for cytoplasmic transport. Alternative mRNA splicing of the the single tau gene on the long arm of human chromosome 17 gives rise to six brain tau proteins that are normally expressed in the adult human central nervous system. Inclusion of a 3aa repeat encoded by exon 10 of the tau gene gives rise to the three isoforms with four microtubule-binding repeats each. The other three isoforms have three repeats each. Tau is mainly a neuronal protein, although its presence in different types of glia cells has been also reported in some neural diseases. Phosphorylation of tau by several phosphatases and kinases like GSK3 and Cdk5 affects its interaction with microtubules, resulting in the destabilisation of microtubules,ultimately leading to the degeneration of the affected neurons. Indeed hyperphosphorylated tau is the essential component of the different aberrant aggregates found in neurons (and sometimes in glia) of patients with neurological disorder like Alzheimers Disease where hyperphosphorylated tau is the major component of paired helical filaments (PHF) and thus neurofibrillary lesions. Filamentous tau protein deposits are also the defining characteristic of otherneurodegenerative diseases, many of which are frontotemporal dementias or movement disorders, such as Pick's disease, progressive supranuclear palsy, and corticobasal degeneration. | | | Catalog # | T1030-02D | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:50-1:100 | | Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50 | | Immunohistochemistry: Frozen | | Optimal dilutions to be determined by the researcher. | | Positive Control | Alzheimer brain | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E353 | | Host | Mouse | | Source | Bovine | | Concentration | As reported | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Purified | | Immunogen | Purified bovine microtubule-associated proteins. Cellular Localization: Cytoplasmic. | | Specificity | Recognizes human Tau. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
