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Anti -Tau (Tau Protein, Microtubule-associated Protein, MAP)
Anti -Tau (Tau Protein, Microtubule-associated Protein, MAP)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH |
|
| Tau protein is named for its ability to serve as a bridge for microtubule formation and stabilization. Tau in PNS neurons is 758aa in length and 110kD in size. It migrates anomalously in SDS-page. Its N-terminus binds plasma membrane components while its C-terminus binds microtubules. The microtubule-binding region contains four consecutive Tau/MAP repeats between aa561-685. Each repeat is 30aa long, Ser/Thr rich, and shows a PGGG motif. Multiple isoforms exist, ranging from 316 to 776aa in length. Various deletions occur within the first 500aa, with some isoforms also showing an absence of the second Tau repeat (aa 592-622). Between aa624-756, human Tau protein shows absolute identity to mouse and dog Tau. | | | Catalog # | T1030-04A | | Applications | Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9L672 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS. No preservative added. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa sequence 404-441 of human Tau. | | Specificity | Recognizes aa sequence 404-441 of human Tau. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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