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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau (microtubule-associated protein tau, DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, Microtubule-associated protein tau, MSTD, MTBT1, MTBT2, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, PPND, tau, TAU)

Anti -Tau (microtubule-associated protein tau, DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549,
Microtubule-associated protein tau, MSTD, MTBT1, MTBT2, Neurofibrillary tangle protein,
Paired helical filament-tau, PHF-tau, PPND, tau, TAU)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Microtubule Associated Proteins, or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4, and tau and are found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.
Catalog #T1030-10A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
ptimal dilutions to be determined by the researcher.
Positive ControlHuman brain tissue lysate.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1k
Clone No9H280
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-Glycine, pH7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenKLH conjugated synthetic linear peptide. Cellular Localization: Cytoplasm cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm cytoskeleton.
SpecificityRecognizes C-terminus region of Tau. Species Crossreactivity: human and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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