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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau, NT (Tau Protein, Microtubule-associated Protein, MAP)

Anti -Tau, NT (Tau Protein, Microtubule-associated Protein, MAP)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Neat Serum E B
Tau proteins are important in the assembly of microtubules. In normal brain, tau is localized within the axons of the neurons, but in some neuropathological lesions, it accumulates within the body of the neuron. Tau proteins are thought to be abnormally phosphorylated in certain disease states. Tau has been immunohistochemically localized to neurofibrillary tangles of Alzheimer’s disease (AD) brains. Tau proteins promote the assembly of tubulin monomers into microtubules and stabilize microtubules. Alternate splicing of tau mRNA, glycosylation, and differential phosphorylation contribute to the heterogeneity of tau.
Catalog #T1030-11
Applications Suitable for use in ELISA using immunizing peptide, Immunohistochemistry (Formalin-fixed, paraffin-embedded sections), Western Blot. Other applications not tested.
Recommended Dilution: ELISA: 1:40,000, IHC: 1:200, Western Blot: 1:5,000; Optimal dilutions to be determined by the researcher.
Storage and Stability May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid with 0.1% sodium azide.
PurityNeat Serum
ImmunogenPeptide (MAEPRQEFEVMEDHAG)
SpecificityN-terminal amino acid sequence 1-16 of human Tau protein
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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