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Abs to Microtubule-associated Proteins
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Anti -Tau (Microtubule-associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-tau, PHF-tau, MAPT, MAPTL, MTBT1)
Anti -Tau (Microtubule-associated Protein Tau, Neurofibrillary Tangle Protein, Paired
Helical Filament-tau, PHF-tau, MAPT, MAPTL, MTBT1)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH Gel |
|
| Tau is a collection of microtubule-associated proteins that is involved in microtubule assembly and stabilization. In adult human brain, 6 isoforms ranging between 352 and 441aa in length are produced as a result of alternative RNA splicing. The expression of tau isoforms is developmentally regulated, as only the smallest tau polypeptide is expressed in fetal brain. Hyperphosphorylated Tau is the major component of the paired helical filament of Alzheimer’s Disease. Phosphorylation-dependent anti-Tau antibodies are used to identify specific aa that are phosphorylated in tau from normal brain and Alzheiner’s disease brain. The Tau proteins, esp. in developing brain and in Alzheimer brains, were found to phosphorylate in vivo at many different sites. | | | Catalog # | T1030-11N | | Applications | Suitable for use in Dot Blot, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Dot Blot: 0.5-2ug/ml | | Western Blot: 0.5-2ug/ml | | Immunohistochemistry: 0.5-2ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide (SPVVSGDT) corresponding to human Tau around Serine 404. | | Specificity | Recognizes human Tau. Species Crossreactivity: mouse, rat, canine and monkey. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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