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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau, phosphorylated (Thr181) (Tau Protein, Microtubule-associated Protein Tau, MAPT, MAPTL, DDPAC, FLJ31424, FTDP-17, MGC138549, MSTD, MTBT1, MTBT2, Neurofibrillary Tangle Protein, Paired Helical Filament-tau, PHF-tau, PPND)

Anti -Tau, phosphorylated (Thr181) (Tau Protein, Microtubule-associated Protein Tau, MAPT,
MAPTL, DDPAC, FLJ31424, FTDP-17, MGC138549, MSTD, MTBT1, MTBT2, Neurofibrillary Tangle
Protein, Paired Helical Filament-tau, PHF-tau, PPND)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Tau is the major microtubule-associated protein in neuronal axons that regulates microtubule stability, neurite outgrowth, and other microtubule -dependent functions. C-terminus of tau protein binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting its role as a linker protein between both. Six tau isoforms are produced in adult human brain by alternative mRNA splicing from a single gene. Filamentous tau protein deposits are the defining characteristic of various neurodegenerative diseases, many of which are frontotemporal dementias or movement disorders, such as Pick's disease, progressive supranuclear palsy, and corticobasal degeneration. Human tau gene is mapped to chromosome 17q21.1.
Catalog #T1032-45
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlMouse brain tissue
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human Tau around the phosphorylation site of threonine 181 (P-K-TP-P-P).
SpecificityRecognizes human Tau when phosphorylated at Thr181. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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