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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau, Phosphorylated (Thr205) (Microtubule-associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-tau, PHF-tau, MAPT, MAPTL, MTBT1)

Anti -Tau, Phosphorylated (Thr205) (Microtubule-associated Protein Tau, Neurofibrillary
Tangle Protein, Paired Helical Filament-tau, PHF-tau, MAPT, MAPTL, MTBT1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B Gel
Tau is a collection of microtubule-associated proteins that is involved in microtubule assembly and stabilization. In adult human brain, 6 isoforms, ranging between 352 and 441aa in length, are produced as a result of alternative RNA splicing. The expression of tau isoforms is developmentally regulated, as only the smallest tau polypeptide is expressed in the fetal brain. Hyperphosphorylated Tau is the major component of the paired helical filament of Alzheimer's disease. Anti-phosphor-Tau antibodies are used to identify specific aa that are phosphorylated in Tau from normal brains and Alzheimer's disease brains. The Tau proteins, especially in developing brains and in Alzheimer brains, can be found to be phosphorylated in vivo at many different sites.
Catalog #T1032-45T
ApplicationsSuitable for use in Western Blot and Dot Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Dot Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05 % sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human Tau at the phosphorylated Threonine 205 (GSPGpTPGSR).
SpecificityRecognizes human Tau, when phosphorylated at Thr205. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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