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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau, phosphorylated (Thr217) (Tau Protein, Microtubule-associated Protein, MAP)

Anti -Tau, phosphorylated (Thr217) (Tau Protein, Microtubule-associated Protein, MAP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Phosphorylation site-specific antibody selective for the phosphorylated form of human
tau containing a phosphate on threonine 217. Tau is a neuronal microtubule-associated
protein found predominantly on axons. The function of tau is to promote tubulin polymerization and stabilize microtubules, but it also serves to link certain signaling pathways to the cytoskeleton. Tau phosphorylation regulates both normal and pathological functions of this protein. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer’s disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK-3b, PKA, PKC, CDK5,
stress-activated protein kinases (SAPKs) and casein kinase II can phosphorylate tau.
Catalog #T1032-59
ApplicationsSuitable for use in Western Blot. Other applications have not been tested.
Recommended DilutionWestern Blot: 0.1-1ug/ml
Optimal dilution to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.4, 1mg/mL BSA (IgG, protease free), 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human tau that contains threonine 217.
SpecificityReacts with human tau phosphorylated at threonine 217.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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