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You are here:Home » Antibodies » Antibodies-Microtubule-associated Proteins » Anti -Tau, phosphorylated (Ser262) (Tau Protein, Microtubule-associated Protein, MAP) (Azide, BSA & Glycerol Free)

Anti -Tau, phosphorylated (Ser262) (Tau Protein, Microtubule-associated Protein, MAP)
(Azide, BSA & Glycerol Free)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Tau is a neuronal microtubule- associated protein found predominantly on axons. The function of tau is to promote tubulin polymerization and stabilize microtubules. Tau, in its hyper-phosphorylated form, is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer’s disease (AD) brain. Hyper-phosphorylated tau is also found in neurofibrillary lesions in a range of other central nervous system disorders. Hyper-phosphorylation impairs the microtubule binding function of tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases, including GSK-3 , protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II, phosphorylate tau. Serine 262 can be phosphorylated by GSK-3 , PKA, CamKII and MARK and has been found to be a major site in AD brain. This antibody, combined with Tau [pS356]), enables one to distinguish between phosphorylation at the two distinct residues, rather than a combined epitope as detected by 12E8 antibody.
Catalog #T1032-60A
ApplicationsSuitable for use in Western blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive Control Used Recombinant human Tau or African green monkey kidney (CV-1) cells, stably expressing human four repeat tau and SV40 small T antigen to induce specific inhibition of PP2A.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2. No preservative added. No stabilizing proteins added. Glycerol-free. Also available with azide, BSA, glycerol. See T1032-60.
PurityPurified by affinity chromatography.
ImmunogenSynthetic phosphopeptide derived from the region of human tau that contains serine 262.
SpecificityRecognizes human Tau. Mouse, rat (92% homologous), bovine, goat, baboon and monkey (100% homologous) tau have not been tested, but are expected to react.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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