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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau phosphorylated S356 (MAPT, MAPTL, MTBT1, TAU, Microtubule-associated protein tau, Neurofibrillary tangle protein;Paired helical filament-tau)

Anti -Tau phosphorylated S356 (MAPT, MAPTL, MTBT1, TAU, Microtubule-associated protein
tau, Neurofibrillary tangle protein;Paired helical filament-tau)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IC
Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).
Catalog #T1032-64C
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:5000-10,000
Immunocytochemistry: 1:100-250
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No10g121
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid in 50mM Tris-Glycine pH 7.4, 0.15M NaCl, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
PuritySupernatant
ImmunogenPhospho-specific peptide corresponding to residues surrounding Serine 356 of human Tau.
SpecificityRecognizes human Tau Phospholated S356.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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