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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau (Tau Protein, Microtubule-associated protein tau, MAPT) (Biotin)

Anti -Tau (Tau Protein, Microtubule-associated protein tau, MAPT) (Biotin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH
Tau is a heterogeneous group of proteins that range in molecular weight from 50-67kD. They are instumental in the assembly of microtubules and have been associated with some disease states. In normal brain, tau is localized in the axons of the neurons but in some neuropathological lesions, it accumulates within the body of the neuron. Tau protein is a microtubule-associated protein predominantly localized to neuronal axons. Tau promotes tubulin polymerization and the stabilization of microtubules. Hyperphosphorylated forms of Tau are the major components of paired helical filaments (PHF) found in the neurofibrillary tangles which characterize Alzheimer’s disease. Alternate splicing of tau mRNA, glycosylation, and differential phosphorylation contribute to the heterogeneity of tau.
Originally, tau was thought to be exclusive to axons but has now been shown present in both somatodendritic and glial compartments of the central nervous system.
Catalog #T1033
ApplicationsSuitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry: 1:1000 (Formalin-fixed paraffin-embedded). May also be used wih formalin-fixed, paraffin-embedded sections of human brain tissue.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No1.B.664
HostMouse
SourceBovine
Concentration0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, 2mM EDTA, 1.0% BSA. Labeled with biotin.
PurityPurified
ImmunogenTau
SpecificityRecognizes an epitope of the (Mr 52-68kD) microtubule associated protein tau in bovine brain. Reacts with tau in the phosphorylated and non-phosphorylated forms in human, bovine monkey and chicken.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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