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Anti -Tau (Tau Protein, Microtubule-associated protein tau, MAPT) (DyLightŪ 488)
Anti -Tau (Tau Protein, Microtubule-associated protein tau, MAPT) (DyLightŪ 488)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Purified |
IC FC |
|
| Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer's disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4). | | | Catalog # | T1033-01 | | Applications | Suitable for use in Flow Cytometry and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1:50 | | Immunocytochemistry: 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Clone No | 10J115 | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.02% sodium azide. Labeled with DyLight® 488. | | Purity | Purified | | Immunogen | Synthetic phospho-peptide corresponding to residues surrounding serine 622 of human Tau. | | Specificity | Recognizes human Tau phosphorylated and unphosphorylated on serine 622. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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