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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau, Whole Molecule (Tau Protein, Microtubule-associated Protein, MAP)

Anti -Tau, Whole Molecule (Tau Protein, Microtubule-associated Protein, MAP)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH
Tau is a heterogeneous group of proteins that range in molecular weight from 50-67kD. They are instumental in the assembly of microtubules and have been associated with some disease states. In normal brain, tau is localized in the axons of the neurons but in some neuropathological lesions, it accumulates within the body of the neuron. Tau protein is a microtubule-associated protein predominantly localized to neuronal axons. Tau promotes tubulin polymerization and the stabilization of microtubules. Hyperphosphorylated forms of Tau are the major components of paired helical filaments (PHF) found in the neurofibrillary tangles which characterize Alzheimer’s disease. Alternate splicing of tau mRNA, glycosylation, and differential phosphorylation contribute to the heterogeneity of tau.
Catalog #T1036
Stains human neurofibrillary tangles, neuropil threads and neuritic plaques, astrocytes and ribosomes. May be used with formalin-fixed paraffin-embedded sections of human brain tissue.
Clone TypeMonoclonal
IsotypeIgG1
Clone No1.B.664
HostMouse
SourceBovine
Concentration~10mg/ml
FormSupplied in 0.01M PBS, pH 7.2, 2mM EDTA, 1.0% BSA, 0.1% sodium azide.
PurityPurified
ImmunogenTau, Whole Molecule
SpecificityRecognizes an epitope of the (Mr 52-68kD) microtubule associated protein tau in bovine brain. Reacts with tau in the phosphorylated and non-phosphorylated forms in human, bovine monkey and chicken.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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