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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau, phosphorylated (S516) (Neurofibrillary Tangles Marker, Microtubule-associated Protein, MAP, Paired helical filament-tau, PHF-tau)

Anti -Tau, phosphorylated (S516) (Neurofibrillary Tangles Marker, Microtubule-associated
Protein, MAP, Paired helical filament-tau, PHF-tau)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1, 2). Tau is hyperphosphorylated at least 25 different sites in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). CDK5, GSK3 beta, and TTBK1 have been linked to phospholyation on Ser 516, which can induce tau aggregation and inhibit tau interaction with Fyn (4,5). With up to 9 different isoforms of Tau, Ser 516 has several orthologous residues, with most popular being Ser 199 of isoform 8.
Catalog #T1040-02J
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:5000-1:20,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E583
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
PuritySupernatant
ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Serine 516 of human Tau.
SpecificityRecognizes human Tau phosphorylated on Serine 516. Species crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesNeurofibrillary tangle protein, Paired helical filament-tau, PHF-tau


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