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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Tau, phosphorylated (S235) (Microtubule-associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-Tau, PHF-tau, MAPTL, MTBT1, TAU, MAPT)

Anti -Tau, phosphorylated (S235) (Microtubule-associated Protein Tau, Neurofibrillary
Tangle Protein, Paired Helical Filament-Tau, PHF-tau, MAPTL, MTBT1, TAU, MAPT)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer’s disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and phosphorylation sites have been implicated in the loss of Tau's association with the membrane cortex during AD progression (3). Many features of AD pathology can be related to the levels and functions of Pin1, a peptidyl-prolyl isomerase that specifically performs cis-trans isomerization at Pro-232 of Tau phosphorylated at Thr-231/Ser-235 (4).
Catalog #T1041-04K
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No11C185
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as liquid in 50mM tris-glycine, pH 7.4, 0.05% BSA, 0.15M sodium chloride, 0.01% sodium azide, 40% glycerol.
PuritySupernatant
ImmunogenPhospho-specific peptide corresponding to residues surrounding Serine 235 of human Tau. Detects only Tau phosphorylated at Serine 235.
SpecificityRecognizes human Tau Phosphorylated (pS235).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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