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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -Microtubule-Associated Protein Tau Isoform 1 (TAU)

Anti -Microtubule-Associated Protein Tau Isoform 1 (TAU)

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Affinity Purified B IH IC
Human Tau protein (a.k.a., “microtubule-associated protein tau isoform 1”) is a 78.902 kD protein (758aa) expressed in cortical neurons of the CNS. In normal individuals, tau contains moderate degrees of phosphorylation on various serine and threonine residues scattered throughout the N-terminal half of this protein. However in various neurodegenerative diseases, such as Alzheimer’s disease, Tau becomes hyperphosphorylated on these residues, leading to the pathological formation of intracellular “neurofibrillary tangles.” Such tangles are hallmarks of Alzheimer’s disease, as well as various other neurodegenerative diseases, collectively known as the “tauopathies.”
Catalog #T1041-05
ApplicationsSuitable for use in Immunohistochemistry, Immunocytochemistry and Western Blot. Other applications have not been tested.
Recommended Dilutions
Immunohistochemistry: 1:10,000-1:20,000 using 2% paraformaldehyde tissues
Immunocytochemistry: 1:10,000-1:20,000 using 2% paraformaldehyde cells
Western Blot: 1:20,000-1:50,000
Optimal dilutions to be determined by the researcher.
Recommended Secondary AntibodiesI1906 IgY, Chicken Pab Rb x Ch
I1906-10 IgY, Chicken (HRP) Rb x Ch
I1906-12 IgY, Chicken (FITC) Rb x Ch
I1906-14 IgY, Chicken (AP) Rb x Ch
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgY
HostChicken
SourceHuman
Concentration~0.2mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenTwo synthetic peptides corresponding to Microtubule-Associated Protein Tau Isoform 1 (KLH). Species sequence homology: mouse (P01637) and human (NP_05819).
SpecificityRecognizes Microtubule-Associated Protein Tau Isoform 1. Species crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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