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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -Tenascin (Cytotactin, Tenascin C, Glioma associated Extracellular Matrix Antigen, GMEM, Hexabrachion)

Anti -Tenascin (Cytotactin, Tenascin C, Glioma associated Extracellular Matrix Antigen,
GMEM, Hexabrachion)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IC
Tenascin is a large glycoprotein that forms disulfide-linked hexamers. Tenascin is made up of a series of repeated structural domains including EGF-like repeats, fibronectin type III repeats, and a region homologous to fibrinogen. Splice variants of tenascin differ in their number of fibronectin type III repeats. Tenascin is expressed in distinctive spatial and temporal patterns in most embryonic tissues at sites of tissue remodeling and cell migration. There is little expression of tenascin in adult tissues except, again, at sites of tissue remodeling and cell migration such as surrounding tumors, in healing wounds, and in branching or damaged blood vessels.
Catalog #T2550-26
Tenascin binds to several cell-surface receptors and mediates cell-substrate adhesion. Nevertheless, tenascin is frequently referred to as an anti-adhesion molecule because for a variety of cell types the presence of tenascin inhibits adhesion to other ECM proteins present. This effect occurs because the binding of tenascin to certain receptors inhibits cell spreading and thereby blocks the stabilization of adhesion that results from cell preading in vitro assays
ApplicationsImmunocytochemistry at 2ug/ml on U251 cells
Immunoblotting (Western) at 2ug/ml to detect whole tenascin under reducing conditions
ELISA: 2 x 10e10 M endpoint dilution
Affinity constant Kd= 2 x 10e10
Storage and Handling Maintain between 2 and 8°C for up to 12 months. For research use only; not for use as a diagnostic
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No2Q561
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.02M Phosphate, 0.25M Sodium Chloride pH 7.6, with 0.1% Sodium Azide
PurityImmunoglobulin purified by Protein A chromatography
ImmunogenPurified human tenascin
SpecificityBinds to a recombinant fragment of human tenascin containing the fibronectin type III repeats, numbers 4 and 5.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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