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Abs to Extracellular Matrix Proteins
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Anti -Tenascin (Cytotactin, Tenascin C, Glioma associated Extracellular Matrix Antigen, GMEM, Hexabrachion)
Anti -Tenascin (Cytotactin, Tenascin C, Glioma associated Extracellular Matrix Antigen,
GMEM, Hexabrachion)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH IC |
|
| Tenascin is a large glycoprotein that forms disulfide-linked hexamers. Tenascin is made up of a series of repeated structural domains including EGF-like repeats, fibronectin type III repeats, and a region homologous to fibrinogen. Splice variants of tenascin differ in their number of fibronectin type III repeats. Tenascin is expressed in distinctive spatial and temporal patterns in most embryonic tissues at sites of tissue remodeling and cell migration. There is little expression of tenascin in adult tissues except, again, at sites of tissue remodeling and cell migration such as surrounding tumors, in healing wounds, and in branching or damaged blood vessels. | | | Catalog # | T2550-28 | | Tenascin binds to several cell-surface receptors and mediates cell-substrate adhesion. Nevertheless, tenascin is frequently referred to as an anti-adhesion molecule because for a variety of cell types the presence of tenascin inhibits adhesion to other ECM proteins present. This effect occurs because the binding of tenascin to certain receptors inhibits cell spreading and thereby blocks the stabilization of adhesion that results from cell preading in vitro assays | | Applications | Immunohistochemistry at 2ug/ml on tissues fixed with cold acetone | | Immunocytochemistry at 2ug/ml on U251 cells | | Immunoblotting (Western) at 2ug/ml to detect whole tenascin under reducing conditions | | ELISA: 2 x 10e10 M endpoint dilution Affinity constant Kd= 6.37 x 10e9 | | | | Storage and Handling | Store at 2 and 8°C for up to 12 months. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1,k | | Clone No | 2Q564 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 0.02 M phosphate, 0.25 M Sodium Chloride pH 7.6, with 0.1% Sodium Azide | | Purity | Immunoglobulin purified by Protein A chromatography. | | Immunogen | Purified human tenascin | | Specificity | Binds to a recombinant fragment of human tenascin containing the fibronectin type III repeats, numbers 1–3 | | | Important Note | This product is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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