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Abs to Extracellular Matrix Proteins
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Anti -Tenascin (Cytotactin, Tenascin C, Glioma associated Extracellular Matrix Antigen, GMEM, Hexabrachion)
Anti -Tenascin (Cytotactin, Tenascin C, Glioma associated Extracellular Matrix Antigen,
GMEM, Hexabrachion)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IH IF |
|
| Tenascins were first characterized in the early 1980’s. Only recently have more elective studies been done. These studies have now attempted to reveal more specific points in carcinogenesis and pathological tissue reactions. It has been demonstrated that tenascin immunoreactivity in breast carcinoma cells could be indicative of metastasis and survival. Recent studies showed that the expression of tenascin in invasion border of early breast cancer significantly correlates with higher risk of distant metastasis. The preliminary results of these studies clearly suggest that expression of tenascin in invasion border of early breast cancer is significantly associated with proliferative activity and higher risk of local recurrence. This result implicates a wide application for tenascin antibodies in the breast pathology. Tenascin expression may suggest situations in which even small breast carcinomas may need more intensive complementary therapy. Recent studies have also shown that tenascin is significantly increased in airway basement membrane of asthmatics and rapidly decreases by inhaled steroid. This suggests that tenascin expression may be used to monitor the disease status and outcome of treatment in different types of asthma. | | | Catalog # | T2550-29A | | Applications | Suitable for use in Immunoprecipitation, Immunofluorecence, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunoprecipitation: Immunoprecipitates Mr 250 and 180kD polypeptides. | | Western Blot: 1:1000 Recognizes the Mr 250kD polypeptide. | | Immunohistochemistry: Formalin-fixed and paraffin embedded sections | | Optimal dilutions to be determined by the researcher. | | Hybridoma | Myeloma cells with spleen cells from Balb/c mice. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | N/A | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 2Q565 | | Host | Mouse | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 1% BSA, 0.1% sodium azide. | | Purity | Purified | | Immunogen | Tenascin polypeptides isolated from spent culture supernatant of human fibroblasts isolated by affinity chromatography. | | Specificity | Recognizes human tenascinthe at 250kD and 180kD. Reacts with the fibrinogen-like knob-domain of tenascin protein especially with human paraffin sections. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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