CTEN, also known as Tensin 4, is a 90kD cytoplasmic protein that is associated with focal adhesions in epithelial cells and is upregulated in several carcinomas. It promotes tumorigenesis by disrupting the attachment of focal adhesions to the cytoskeleton, promoting epithelial-mesenchymal transition, and binding nuclear beta-Catenin. CTEN is cleaved by Caspase-3 at aa570-571 during apoptosis. It contains a serine-rich region aa168-324, one SH2 domain aa449-556, and a phosphatase domain aa548-714. Within aa1-107, human CTEN shares 62% and 59% aa sequence identity with mouse and rat CTEN.
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