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You are here:Home » Biochemicals » Biochem-Antibiotics » Thiostrepton (Bryamycin, Thiactin, Alaninamide, Antibiotic X 146, Antibiotic A 8506, Antibiotic 6761-31)

Thiostrepton (Bryamycin, Thiactin, Alaninamide, Antibiotic X 146, Antibiotic A 8506,
Antibiotic 6761-31)

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Specifications

Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S riobsomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, members of the MerR proteins that are central regulators in multidrug resistance. Closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor-FoxM1.
Catalog #T3792-12
DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water
CAS Number1393-48-2
Molecular FormulaC72H85N19O18S5
Molecular Weight1664.9
SourceStreptomyces sp.
Purity> 99% by HPLC
FormWhite solid
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesBryamycin, Thiactin, Alaninamide, Antibiotic X 146, Antibiotic A 8506, Antibiotic 6761-31


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